Representative packaging image · verify the ordered lot
Decision summary
Key benefits
The supported B2B value is as a defined cosmetic-formulation research active with a traceable sequence and manufacturer technical history
Wrinkle-depth percentages, rapid visible improvement, superiority to Argireline and muscle-relaxation claims are primarily manufacturer or indirect evidence
Multi-active microneedle studies can support formulation hypotheses but cannot establish the independent contribution of SNAP-8.
Published research context is presented for literature orientation only. It is not a dosing, treatment or human-use instruction.
Qualification data
Specifications to confirm against the released lot
CAS
868844-74-0
Formula
C41H70N16O16S
Molecular weight
1075.2 g/mol
Appearance
Lyophilized material; confirm released-lot appearance on the COA
Purity
Confirm chromatographic purity and net peptide content separately on the batch COA · target, verify batch COA
Storage
Follow the batch COA and stability data for the exact form. Cayman specifies -20°C and at least four years for its solid research reagent, while Lubrizol's aqueous trade solution has different excipients and specifications. Neither statement automatically applies to another supplier's lyophilized lot or a finished cosmetic. Protect methionine-containing material from unvalidated oxidation, heat, light and repeated freeze-thaw exposure.
MOQ
1 kit (10 vials) per SKU
Lead time
Confirmed with quote
Qualification matrix
Identity, purity and content are separate release questions.
Identity
Confirm the stated molecule and supplied form. Start with the matching batch COA; request sequence-level evidence only when the buyer's written procedure requires it and availability or a separate scope has been agreed.
Purity
Review RP-HPLC method conditions, wavelength, integration and related-peak handling. A percentage without the method is not enough.
Content
Net peptide content is not the same as gross lyophilized powder weight. Ask which assay supports the stated amount and whether water/counter-ion is addressed.
Stability
Follow the storage condition stated on the batch COA or label from receipt onward.
Research context
What researchers study about SNAP-8
SNAP-8 is the trade name commonly associated with Acetyl Octapeptide-3, an acetylated, C-terminally amidated cosmetic-research peptide derived from the SNAP-25-mimetic design concept. Manufacturer materials position it for the appearance of expression lines, but direct independent human evidence for SNAP-8 alone is sparse. The available human patch studies used multi-active microneedle formulations, so their outcomes cannot be attributed to this peptide alone. Describing SNAP-8 as a topical botulinum-toxin substitute overstates both clinical evidence and demonstrated delivery to the neuromuscular target.
Appropriate uses include cosmetic formulation screening, peptide stability and delivery studies, SNARE-related in vitro assays, and analytical method development
Expression-line outcomes remain a cosmetic appearance hypothesis with limited independent single-ingredient evidence
Multi-active microneedle results and Argireline trials must not be presented as SNAP-8-alone efficacy.
Mechanism context
The question the literature is testing
SNAP-8 was designed from a SNAP-25 N-terminal motif and is proposed to interfere with SNARE-complex assembly in model systems. Evidence from longer SNAP-25 fragments and the related hexapeptide Argireline supports the design rationale, but it does not prove that topically formulated SNAP-8 reaches an intact human neuromuscular junction at an effective concentration. Skin penetration, stability, target engagement and clinical relevance depend on the finished formulation and remain important evidence gaps.
Evidence map
Research routes and exposure context
Evidence tierAnalytical / laboratory contextResearch areaOther research materialsRoutes reported in sources
Topical
Dose / exposure contextProtocol-specific; verify the cited primary source
Routes and exposure contexts summarize cited studies or approved finished-product labels. They are not instructions for administering this RUO material; no customer dose is provided.
Evidence boundaries
Compatibility, limitations and decision context
Raw SNAP-8 powder is not a finished cosmetic and is not for injection
The multi-ingredient patch studies reported local tolerability for their tested formulations, not universal safety of pure peptide
No adequate basis was found for blanket pregnancy or breastfeeding prohibitions, a claim of zero systemic absorption, or broad suitability for sensitive or periocular skin
Finished products require region-specific cosmetic safety assessment, microbiological control, stability, packaging compatibility, exposure evaluation and appropriate human compatibility testing.
Interactions reported in the literature
No validated clinical synergy or incompatibility matrix exists for Argireline, Leuphasyl, Matrixyl, hyaluronic acid, ascorbyl glucoside, GHK-Cu, niacinamide, retinoids or acids
Formulators should test pH, ionic strength, metal binding, methionine oxidation, proteolysis, adsorption, preservative compatibility and assay interference in the complete formula rather than relying on layering advice.
Literature context is not a supplier release result or human-use instruction. Follow your institution's approved laboratory risk assessment.
Batch documentation
SNAP-8 batch COAs
Laboratory: Manufacturer's QC laboratoryTests: HPLC purity · MS identity · endotoxin · fill amount
10 mg
100 mg
Previews are blurred on purpose so the documents cannot be reused; third-party reports show their first page only. Sales sends the clear full version for the product and strength you ask about.
Published COAs show recent representative batches and may not be the newest. For a quote or shipment, sales confirms the lot and sends its COA.
Third-party reports, added progressively
Previews of the first page of third-party reports are on our Quality page and on the matching product pages; sales sends the full report on request. You can also send any vial from your order to an independent laboratory of your choice. Unless agreed otherwise in writing, the buyer pays for optional testing.
Help reviewing your COA
Need help reading a batch COA or third-party report? Sales can explain the test items, specifications and how the results relate to the lot under discussion.
On every batch COA: HPLC purity · MS identity · endotoxin · fill amount · Verify LyoPep
Third-party reports for SNAP-8
Reports from Qorix (tjqxgd.com), a third-party analytical laboratory in Tianjin, China: HPLC purity and MS identity of the sample tested.
Laboratory: Third-party laboratoryTests: HPLC purity · MS identity
10 mg
Previews are blurred on purpose so the documents cannot be reused; third-party reports show their first page only. Sales sends the clear full version for the product and strength you ask about.
Ask for the current packet, not a generic certificate
Require sequence and terminal-modification confirmation by high-resolution intact mass plus MS/MS or peptide mapping, chromatographic purity with impurity profile, quantitative peptide content, methionine-oxidation and deamidation controls, counterion, water, residual solvents and lot-specific stability
For cosmetic manufacture also require bioburden or microbial limits, preservative-system compatibility and formulation recovery
Appearance and a nominal HPLC area percentage alone are insufficient.
Batch COA for the released lotHPLC purity with method contextMS identity resultEndotoxin resultFill amount (measured content per vial)SDS and handling statement
Available fills
Quote the fill and pack configuration you need
Reference SKUFillBase pack
NP81010 mg10 vials
NP8100100 mg10 vials
Other format
Also available as a nasal spray (US stock)
10 mL nasal spray bottle
Besides lyophilized vials, SNAP-8 is also supplied as a nasal spray solution, shipped from our US stock.
Strengths
10 mg
Bottle sizes
10 mL or 20 mL
Minimum order
10 bottles per strength and bottle size
Ships from
Our US stock
Handling
Plan storage before the parcel arrives
Follow the batch COA and stability data for the exact form. Cayman specifies -20°C and at least four years for its solid research reagent, while Lubrizol's aqueous trade solution has different excipients and specifications. Neither statement automatically applies to another supplier's lyophilized lot or a finished cosmetic. Protect methionine-containing material from unvalidated oxidation, heat, light and repeated freeze-thaw exposure.
State the destination and timing so receipt can be planned, then move the material into its stated storage condition on arrival.
Buyer FAQ
Terms to settle before the purchase order
Can a buyer arrange third-party testing?+
Yes. You can send any vial from your order to an independent laboratory of your choice. If you want the laboratory, specification, sampling, method and acceptance rule agreed with us before testing, sales confirms them in writing. Unless otherwise agreed in writing, the buyer pays the cost of this optional testing.
What if my own lab test shows the product is out of specification?+
Send any vial from your order to an independent laboratory of your choice. If the report shows the product does not meet the specification on its COA — purity below the stated minimum, or an identity that does not match — share the report with our sales team and we refund that product in full.
Does HPLC purity prove peptide content?+
No. Chromatographic purity describes the relative peak profile under a stated method. Identity, water, counter-ion, residual solvents and assay/content may require separate methods.
How should material be stored after delivery?+
Move it into the storage condition stated on the batch COA or label as soon as it arrives, and record the package condition on receipt.
How are payment terms handled?+
Available methods and milestones depend on order value, destination and project type. The pro forma invoice should state currency, bank details, fees, payment milestones and the release condition.
Why must the testing laboratory understand peptide chemistry?+
Free-base and salt forms, hydrophilic and hydrophobic sequences, aggregation and adsorption can change sample preparation and method suitability. Use a laboratory experienced with the molecule class.
These are buyer-qualification references, not claims that this RUO material is regulated, certified or released under those frameworks. Applicability depends on the buyer's workflow and jurisdiction.
Selected sources
Literature behind the research context
The 2024 Annals of Dermatology and earlier microneedle studies evaluated multi-active patches containing SNAP-8; they do not isolate its effect. The 2025 cosmeceutical review supplies current secondary context but repeats a disputed identity value. The 2004 SNAP-25-fragment paper and 2002 Argireline paper are mechanistic lineage, not SNAP-8 clinical trials. Lubrizol is the primary manufacturer source for trade-solution composition and claims; Cayman and NCATS support identity; the European Commission CosIng database is informative and does not itself authorize an ingredient or finished product.
01
Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Having Dual Anti-Wrinkle Effects With Safe and Long-Term Activities
Annals of Dermatology · 2024 · peer-reviewed original research (randomized, placebo-controlled clinical study)
How is SNAP-8 distinguished from Acetyl Hexapeptide-8 (Argireline)?+
SNAP-8 is commonly associated with Acetyl Octapeptide-3, sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂. Acetyl Hexapeptide-8/Argireline is a different six-residue peptide. Specify the complete sequence, N-terminal acetylation, C-terminal amidation, stereochemistry and methionine-oxidation limit; trade names, a CAS or an HPLC retention time alone do not establish that the correct peptide was supplied.
Does a manufacturer’s 3–10% use level mean 3–10% pure SNAP-8 peptide?+
No. The cited 3–10% recommendation applies to Lubrizol’s aqueous SNAP-8 trade solution, which contains water, Acetyl Octapeptide-3 and caprylyl glycol. A formulator must obtain the trade solution’s active assay and calculate the actual peptide concentration. Copying that percentage to pure lyophilized powder would create a major concentration error. Finished-formula pH, preservative compatibility, recovery, delivery and safety still require validation.
What evidence and batch data should a buyer require for SNAP-8?+
Independent human evidence for SNAP-8 alone is limited; multi-active microneedle studies and Argireline data cannot establish its individual effect or skin delivery. For the raw material, require high-resolution intact mass plus sequence-confirming identity, chromatographic purity with impurity assignment, quantitative peptide content, methionine oxidation and deamidation controls, counterion, water, residual solvents and lot-specific stability. A finished cosmetic also needs microbiological, preservative, packaging, exposure and compatibility assessment.
