Bronchogen

Name: Bronchogen
Brand: LyoPep

AEDL tetrapeptide research reference · sequence-resolved identity is essential

Lot-specific · Batch COACAS 857267-12-0RUO

Batch COA

MOQ1 kit (10 vials) per SKU

Supplied formLinear tetrapeptide; H-Ala-Glu-Asp-Leu-OH (AEDL)

Lead time14–21 days

Bronchogen — Lot-specific lyophilized research peptide; confirm colour and cake condition on the released-lot COA

Bronchogen — Lot-specific lyophilized research peptide; confirm colour and cake condition on the released-lot COA · Representative packaging image · verify the ordered lot

Representative packaging image · verify the ordered lot

Decision summary

Key benefits

Useful laboratory questions include sequence-isomer discrimination, bronchial-cell gene-expression and promoter-methylation assays, and replication of preclinical respiratory-tissue findings with sequence-confirmed material
The record deliberately separates AEDL evidence from ADEL studies and from brand-only reports.

Published research context is presented for literature orientation only. It is not a dosing, treatment or human-use instruction.

Qualification data

Specifications to confirm against the released lot

CAS: 857267-12-0
Formula: C₁₈H₃₀N₄O₉
Molecular weight: 446.5 g/mol
Appearance: Lot-specific lyophilized research peptide; confirm colour and cake condition on the released-lot COA
Purity: Lot-specific chromatographic purity and quantitative peptide content; confirm both on the released-lot COA · target, verify batch COA
Storage: Follow the released-lot COA, SDS and formulation-specific stability statement. Temperature, light protection, container, shipping range and any post-preparation hold time require evidence for the exact AEDL form, matrix and concentration; generic vendor instructions are not a stability study.
MOQ: 1 kit (10 vials) per SKU
Lead time: 14–21 days

PubChem CID 11690869

Qualification matrix

Identity, purity and content are separate release questions.

Identity

Confirm the stated molecule and supplied form. Start with the matching batch COA; request sequence-level evidence only when the buyer's written procedure requires it and availability or a separate scope has been agreed.

Purity

Review RP-HPLC method conditions, wavelength, integration and related-peak handling. A percentage without the method is not enough.

Content

Net peptide content is not the same as gross lyophilized powder weight. Ask which assay supports the stated amount and whether water/counter-ion is addressed.

Stability

Follow the storage condition stated on the batch COA or label from receipt onward.

Research context

What researchers study about Bronchogen

Bronchogen is marketed within the Khavinson research lineage and is specified here as H-Ala-Glu-Asp-Leu-OH, AEDL. PubChem CID 11690869 supports formula C₁₈H₃₀N₄O₉ and molecular weight approximately 446.5 Da for AEDL. The literature is chemically inconsistent: PMID 25761685 explicitly studies AEDL, whereas PMID 21240358 and PMID 25015171 explicitly study ADEL, an order isomer with the same composition and intact mass. PMID 26468022 names Bronchogen in a rat model but its accessible abstract does not state the sequence. These materials cannot be assumed equivalent. The evidence is mainly in vitro or animal based, concentrated in one research lineage and not independently replicated as a sequence-confirmed human programme.

Sequence-resolved in-vitro bronchial epithelial gene-expression and promoter-methylation research; analytical comparison of AEDL, ADEL and related tetrapeptides; and carefully qualified preclinical replication
These are research applications, not clinical indications.

Mechanism context

The question the literature is testing

PMID 25761685 reports AEDL-associated changes in bronchial-cell gene expression and selected promoter methylation. More detailed DNA-binding findings often attributed to Bronchogen derive from ADEL papers and are related-programme hypotheses, not direct proof for AEDL. A causal chain from sequence-confirmed AEDL binding through chromatin regulation to organism-level outcomes has not been independently demonstrated. Cell entry, promoter recognition and durable transcriptional effects remain testable hypotheses.

Evidence map

Research routes and exposure context

Evidence tierMixed evidence context

Research areaKhavinson bioregulators

Routes reported in sources

No administration route applies

Dose / exposure contextProtocol-specific; verify the cited primary source

Routes and exposure contexts summarize cited studies or approved finished-product labels. They are not instructions for administering this RUO material; no customer dose is provided.

Evidence boundaries

Compatibility, limitations and decision context

Not for human or veterinary use
Small preclinical reports without an observed severe signal do not establish human tolerability, long-term safety, sterility or administration suitability
Follow the SDS and institutional controls; keep sequence identity and RUO status explicit in procurement and laboratory records.

Interactions reported in the literature

No controlled combination or interaction evidence was identified for sequence-confirmed AEDL
Supplier “stacks” and other Khavinson products are not validated combinations and no patient interaction advice is provided.

Literature context is not a supplier release result or human-use instruction. Follow your institution's approved laboratory risk assessment.

Batch documentation

Bronchogen batch COAs

Laboratory: Manufacturer's QC laboratoryTests: HPLC purity · MS identity · endotoxin · fill amount

20 mg

Previews are blurred on purpose so the documents cannot be reused; third-party reports show their first page only. Sales sends the clear full version for the product and strength you ask about.

Independent test fails? Full refund.

Representative records, refreshed periodically

Published COAs show recent representative batches and may not be the newest. For a quote or shipment, sales confirms the lot and sends its COA.

Third-party reports, added progressively

Previews of the first page of third-party reports are on our Quality page and on the matching product pages; sales sends the full report on request. You can also send any vial from your order to an independent laboratory of your choice. Unless agreed otherwise in writing, the buyer pays for optional testing.

Help reviewing your COA

Need help reading a batch COA or third-party report? Sales can explain the test items, specifications and how the results relate to the lot under discussion.

On every batch COA: HPLC purity · MS identity · endotoxin · fill amount · Verify LyoPep

Ask for the current packet, not a generic certificate

Require exact N-to-C AEDL sequence, termini, supplied form and counterion; theoretical and observed high-resolution intact mass
LC-MS/MS fragment-ion evidence that distinguishes ADEL and other order isomers; stability-indicating HPLC purity and impurity profile; quantitative peptide content; water, counterion and relevant residuals; and a lot-specific stability basis
Sterility, bacterial endotoxin and bioburden are separate tests
Colour, a trade name or a single HPLC area percentage cannot establish identity or fitness for a method.

Batch COA for the released lotHPLC purity with method contextMS identity resultEndotoxin resultFill amount (measured content per vial)SDS and handling statement

Available fills

Quote the fill and pack configuration you need

Reference SKUFillBase pack

BRO2020 mg10 vials

Handling

Plan storage before the parcel arrives

Follow the released-lot COA, SDS and formulation-specific stability statement. Temperature, light protection, container, shipping range and any post-preparation hold time require evidence for the exact AEDL form, matrix and concentration; generic vendor instructions are not a stability study.

State the destination and timing so receipt can be planned, then move the material into its stated storage condition on arrival.

Buyer FAQ

Terms to settle before the purchase order

Can a buyer arrange third-party testing?+

Yes. You can send any vial from your order to an independent laboratory of your choice. If you want the laboratory, specification, sampling, method and acceptance rule agreed with us before testing, sales confirms them in writing. Unless otherwise agreed in writing, the buyer pays the cost of this optional testing.

What if my own lab test shows the product is out of specification?+

Send any vial from your order to an independent laboratory of your choice. If the report shows the product does not meet the specification on its COA — purity below the stated minimum, or an identity that does not match — share the report with our sales team and we refund that product in full.

Does HPLC purity prove peptide content?+

No. Chromatographic purity describes the relative peak profile under a stated method. Identity, water, counter-ion, residual solvents and assay/content may require separate methods.

How should material be stored after delivery?+

Move it into the storage condition stated on the batch COA or label as soon as it arrives, and record the package condition on receipt.

How are payment terms handled?+

Available methods and milestones depend on order value, destination and project type. The pro forma invoice should state currency, bank details, fees, payment milestones and the release condition.

Why must the testing laboratory understand peptide chemistry?+

Free-base and salt forms, hydrophilic and hydrophobic sequences, aggregation and adsorption can change sample preparation and method suitability. Use a laboratory experienced with the molecule class.

External qualification references

WHO good storage and distribution practices ISO/IEC 17025 laboratory competence 21 CFR 211.84 component testing and supplier COA controls

These are buyer-qualification references, not claims that this RUO material is regulated, certified or released under those frameworks. Applicability depends on the buyer's workflow and jurisdiction.

Selected sources

Literature behind the research context

Identity: PubChem CID 11690869 for AEDL, formula C₁₈H₃₀N₄O₉ and molecular weight approximately 446.5 Da. Sequence-matched context: PMID 25761685 explicitly identifies AEDL. Identity-conflicted context: PMID 21240358 and PMID 25015171 explicitly identify ADEL; PMID 26468022 names Bronchogen but does not state a sequence in the accessible abstract. No sequence-confirmed human pharmacokinetic or randomized clinical study was identified.

01
Peptide regulation of gene expression and protein synthesis in bronchial epithelium
Lung · 2014 · peer-reviewed original research (in vitro, human bronchial epithelial cell culture)
Open source
02
Modulating effect of peptide therapy on the morphofunctional state of bronchial epithelium in rats with obstructive lung pathology
Bulletin of Experimental Biology and Medicine · 2015 · peer-reviewed original research (in vivo, rat model of COPD)
Open source
03
Epigenetic mechanisms of peptidergic regulation of gene expression during aging of human cells
Biochemistry (Moscow) · 2015 · peer-reviewed review/research article
Open source
04
Effect of the peptide bronchogen (Ala-Asp-Glu-Leu) on DNA thermostability
Bulletin of Experimental Biology and Medicine · 2011 · peer-reviewed original research (biophysical/in vitro)
Open source
05
Peptide regulation of gene expression: a systematic review
Molecules · 2021 · peer-reviewed systematic review
Open source

Product FAQ

Questions buyers ask about Bronchogen

How can AEDL Bronchogen be distinguished from related tetrapeptides and sequence isomers?+

Bronchogen is specified here as AEDL. Epitalon is AEDG and Cortagen is AEDP, so adequately resolved intact mass can distinguish those different compositions. Intact mass alone cannot distinguish AEDL from ADEL or other order isomers with the same elemental composition. Qualification therefore requires the exact N-to-C sequence, termini and supplied form plus LC-MS/MS evidence covering diagnostic fragment ions; a trade name, formula or generic purity result is insufficient.

What does the published Bronchogen evidence actually support?+

The sequence-matched AEDL literature is limited mainly to in-vitro bronchial-cell gene-expression and promoter-methylation research. Other papers explicitly study ADEL, while a rat obstructive-lung abstract names Bronchogen without stating the sequence. These records support sequence-resolved preclinical investigation, not interchangeable attribution across isomers and not a human efficacy or safety claim.

Which released-lot evidence is most important for Bronchogen?+

Request the exact AEDL sequence written N-to-C, terminal state, salt/counterion and theoretical mass; high-resolution intact mass; LC-MS/MS sequence-ion coverage able to distinguish ADEL; stability-indicating HPLC purity and impurity profile; quantitative peptide content; water, counterion and relevant residuals; and the lot-specific storage basis. Sterility and bacterial endotoxin are separate attributes and should be claimed only with named methods and acceptance limits.

Evidence before order

Bronchogen

Key benefits

Specifications to confirm against the released lot

Identity, purity and content are separate release questions.

What researchers study about Bronchogen

The question the literature is testing

Research routes and exposure context

Compatibility, limitations and decision context

Interactions reported in the literature

Bronchogen batch COAs

Ask for the current packet, not a generic certificate

Quote the fill and pack configuration you need

Plan storage before the parcel arrives

Terms to settle before the purchase order

Literature behind the research context

Peptide regulation of gene expression and protein synthesis in bronchial epithelium

Modulating effect of peptide therapy on the morphofunctional state of bronchial epithelium in rats with obstructive lung pathology

Epigenetic mechanisms of peptidergic regulation of gene expression during aging of human cells

Effect of the peptide bronchogen (Ala-Asp-Glu-Leu) on DNA thermostability

Peptide regulation of gene expression: a systematic review

Questions buyers ask about Bronchogen

Buyer intelligence

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