Pinealon

Name: Pinealon
Brand: LyoPep

Khavinson neuroprotective tripeptide (Glu-Asp-Arg, EDR)

≥ 99.0% · target, verify batch COACAS 175175-23-2RUO

Batch COA

MOQ1 kit (10 vials) per SKU

Supplied formTripeptide (linear)

Lead time14–21 days

Pinealon — White to off-white lyophilized powder

Representative packaging image · verify the ordered lot

Decision summary

Key benefits

Evidence-supported research topics are oxidative-stress and cell-viability assays, neuronal morphology, neuroprotection hypotheses and peptide-nucleic-acid interaction
Rat, 5xFAD mouse and induced-neuron results are preclinical and cannot establish treatment of traumatic brain injury, Alzheimer's disease, cognitive decline, sleep disturbance or aging in humans
A 2020 review summarizes historical oral observations in 72 patients, but the underlying original reports are not sufficiently accessible here for independent appraisal and do not justify a clinical efficacy claim.

Published research context is presented for literature orientation only. It is not a dosing, treatment or human-use instruction.

Qualification data

Specifications to confirm against the released lot

CAS: 175175-23-2
Formula: C₁₅H₂₆N₆O₈
Molecular weight: 418.4 g/mol
Appearance: White to off-white lyophilized powder
Purity: ≥ 99.0% · target, verify batch COA
Storage: Store the unopened lyophilized material according to the batch COA and lot-specific stability statement, protected from moisture and light. Reconstituted stability depends on counterion, buffer, concentration, container, temperature and microbial controls; do not assign a universal dating period without validated data. Minimize unvalidated freeze-thaw cycles and document temperature excursions.
MOQ: 1 kit (10 vials) per SKU
Lead time: 14–21 days

PubChem CID 10273502

Qualification matrix

Identity, purity and content are separate release questions.

Identity

Confirm the stated molecule and supplied form. Start with the matching batch COA; request sequence-level evidence only when the buyer's written procedure requires it and availability or a separate scope has been agreed.

Purity

Review RP-HPLC method conditions, wavelength, integration and related-peak handling. A percentage without the method is not enough.

Content

Net peptide content is not the same as gross lyophilized powder weight. Ask which assay supports the stated amount and whether water/counter-ion is addressed.

Stability

Follow the storage condition stated on the batch COA or label from receipt onward.

Research context

What researchers study about Pinealon

Pinealon is the defined tripeptide Glu-Asp-Arg (EDR) investigated in a body of short-peptide bioregulator research associated primarily with the St. Petersburg Khavinson group. Peer-reviewed studies report antioxidant and cell-survival observations in vitro, effects in rat and transgenic mouse models, nuclear localization or nucleic-acid interaction experiments, and induced-neuron morphology findings. These studies support research hypotheses, not established therapeutic efficacy. The literature is concentrated within a connected research lineage, independent replication is limited, and no qualifying completed randomized controlled human trial was identified in this review. Cortexin is a heterogeneous animal-tissue polypeptide preparation; Pinealon is a single defined synthetic sequence and must not be represented as the same product.

Appropriate research contexts include oxidative-stress and cell-viability assays, neuronal morphology and dendritogenesis models, peptide-nucleic-acid interaction studies, and exploratory neurodegeneration models
Published rat, mouse and induced-neuron observations are not clinical indications
Historical human observations cited by reviews are low-certainty context and do not establish efficacy for traumatic brain injury, cognitive impairment, Alzheimer's disease, sleep or anti-aging use.

Mechanism context

The question the literature is testing

Proposed mechanisms include reduced reactive-oxygen-species accumulation, altered ERK1/2 timing, changes in apoptosis-related and antioxidant markers, dendritic-spine preservation in model systems, and sequence-dependent interaction with nucleic-acid structures. Some papers propose effects on gene-expression regulation, but direct binding observations and model-specific biomarker changes do not by themselves prove a clinically relevant epigenetic mechanism in humans. Formal human pharmacokinetic, target-engagement and dose-response evidence remains unavailable.

Evidence map

Research routes and exposure context

Evidence tierMixed evidence context

Research areaNeurocognitive research

Routes reported in sources

OralIn vitro

Dose / exposure contextProtocol-specific; verify the cited primary source

Routes and exposure contexts summarize cited studies or approved finished-product labels. They are not instructions for administering this RUO material; no customer dose is provided.

Evidence boundaries

Compatibility, limitations and decision context

A complete human safety, immunogenicity, reproductive-toxicity, genotoxicity and long-term exposure profile has not been established
Preclinical publications and limited historical reports cannot support a general safety conclusion
This commercial material is for research use only and is not for human or veterinary administration, diagnosis or treatment
Laboratory handling requires the SDS, institutional risk assessment and appropriate containment.

Interactions reported in the literature

No validated human interaction, combination or stacking evidence was identified
Mentions of Epitalon, Cortexin, Semax, Selank, melatonin, BPC-157, NAD+ or other peptides in community protocols do not establish pharmacologic synergy, compatibility or safety
In laboratory mixtures, assess solubility, adsorption, oxidation, counterion, pH and analytical interference for each design rather than assuming compatibility.

Literature context is not a supplier release result or human-use instruction. Follow your institution's approved laboratory risk assessment.

Batch documentation

Pinealon batch COAs

Laboratory: Manufacturer's QC laboratoryTests: HPLC purity · MS identity · endotoxin · fill amount

5 mg
10 mg

Previews are blurred on purpose so the documents cannot be reused; third-party reports show their first page only. Sales sends the clear full version for the product and strength you ask about.

Independent test fails? Full refund.

Representative records, refreshed periodically

Published COAs show recent representative batches and may not be the newest. For a quote or shipment, sales confirms the lot and sends its COA.

Third-party reports, added progressively

Previews of the first page of third-party reports are on our Quality page and on the matching product pages; sales sends the full report on request. You can also send any vial from your order to an independent laboratory of your choice. Unless agreed otherwise in writing, the buyer pays for optional testing.

Help reviewing your COA

Need help reading a batch COA or third-party report? Sales can explain the test items, specifications and how the results relate to the lot under discussion.

On every batch COA: HPLC purity · MS identity · endotoxin · fill amount · Verify LyoPep

Third-party reports for Pinealon

Reports from Qorix (tjqxgd.com), a third-party analytical laboratory in Tianjin, China: HPLC purity and MS identity of the sample tested.

Laboratory: Third-party laboratoryTests: HPLC purity · MS identity

10 mg

Previews are blurred on purpose so the documents cannot be reused; third-party reports show their first page only. Sales sends the clear full version for the product and strength you ask about.

Ask for the current packet, not a generic certificate

Appearance is only a preliminary check and cannot establish identity, purity, peptide content, counterion or sterility
Procurement should require the full sequence and terminal state, counterion identity and quantity, high-resolution intact mass, sequence-confirming MS/MS or peptide mapping, chromatographic purity with raw data and impurity profile, quantitative peptide content, water, residual solvents and lot-specific stability
If sterility, endotoxin or bioburden is claimed, require separate validated results
A clear solution after reconstitution does not prove batch conformity.

Batch COA for the released lotHPLC purity with method contextMS identity resultEndotoxin resultFill amount (measured content per vial)SDS and handling statement

Available fills

Quote the fill and pack configuration you need

Reference SKUFillBase pack

PIN55 mg10 vials

PIN1010 mg10 vials

PIN2020 mg10 vials

Handling

Plan storage before the parcel arrives

Store the unopened lyophilized material according to the batch COA and lot-specific stability statement, protected from moisture and light. Reconstituted stability depends on counterion, buffer, concentration, container, temperature and microbial controls; do not assign a universal dating period without validated data. Minimize unvalidated freeze-thaw cycles and document temperature excursions.

State the destination and timing so receipt can be planned, then move the material into its stated storage condition on arrival.

Buyer FAQ

Terms to settle before the purchase order

Can a buyer arrange third-party testing?+

Yes. You can send any vial from your order to an independent laboratory of your choice. If you want the laboratory, specification, sampling, method and acceptance rule agreed with us before testing, sales confirms them in writing. Unless otherwise agreed in writing, the buyer pays the cost of this optional testing.

What if my own lab test shows the product is out of specification?+

Send any vial from your order to an independent laboratory of your choice. If the report shows the product does not meet the specification on its COA — purity below the stated minimum, or an identity that does not match — share the report with our sales team and we refund that product in full.

Does HPLC purity prove peptide content?+

No. Chromatographic purity describes the relative peak profile under a stated method. Identity, water, counter-ion, residual solvents and assay/content may require separate methods.

How should material be stored after delivery?+

Move it into the storage condition stated on the batch COA or label as soon as it arrives, and record the package condition on receipt.

How are payment terms handled?+

Available methods and milestones depend on order value, destination and project type. The pro forma invoice should state currency, bank details, fees, payment milestones and the release condition.

Why must the testing laboratory understand peptide chemistry?+

Free-base and salt forms, hydrophilic and hydrophobic sequences, aggregation and adsorption can change sample preparation and method suitability. Use a laboratory experienced with the molecule class.

External qualification references

WHO good storage and distribution practices ISO/IEC 17025 laboratory competence 21 CFR 211.84 component testing and supplier COA controls

These are buyer-qualification references, not claims that this RUO material is regulated, certified or released under those frameworks. Applicability depends on the buyer's workflow and jurisdiction.

Selected sources

Literature behind the research context

The evidence set comprises the 2011 cell-viability paper, the 2012 prenatal-hyperhomocysteinemia rat study, the 2011 HeLa-cell/nucleic-acid interaction paper, the 2020 EDR review, the 2021 5xFAD mouse study and its 2025 correction, the 2022 neuroepigenetics review, the 2024 induced-neuron study and a 2013 Russian-language review with an English abstract. These sources are useful for research context but are largely connected to the same research lineage. No source reviewed validates the commonly marketed 5 mg subcutaneous protocol or a completed randomized controlled human efficacy trial.

01
Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes
Rejuvenation Research · 2011 · peer-reviewed original research (in vitro)
Open source
02
Pinealon protects the rat offspring from prenatal hyperhomocysteinemia
International Journal of Clinical and Experimental Medicine · 2012 · peer-reviewed original research (in vivo, rat model)
Open source
03
Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA
Biochemistry (Moscow) · 2011 · peer-reviewed original research (in vitro, mechanistic)
Open source
04
EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease
Molecules · 2020 · peer-reviewed review article
Open source
05
Neuroepigenetic Mechanisms of Action of Ultrashort Peptides in Alzheimer's Disease
International Journal of Molecular Sciences · 2022 · peer-reviewed review article
Open source
06
Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes
International Journal of Molecular Sciences · 2024 · peer-reviewed original research (in vitro)
Open source
07
Neuroprotective Effects of Peptide Bioregulators in People of Various Age
Advances in Gerontology (Uspekhi Gerontologii) · 2013 · peer-reviewed review article
Open source
08
PubChem Compound Summary: Pinealon
PubChem · 2026 · authoritative chemical identity database
Open source

Product FAQ

Questions buyers ask about Pinealon

How should Pinealon be understood within the Khavinson peptide literature?+

Pinealon is the short sequence Glu-Asp-Arg (EDR) studied within the Khavinson peptide-bioregulator literature. Publications relate it to the research lineage of Cortexin, a heterogeneous cortex-derived polypeptide preparation, but Pinealon is a defined synthetic tripeptide rather than Cortexin itself. Proposed DNA-, gene-expression- and neuroprotection mechanisms remain research hypotheses supported mainly by one connected research network; they are not proof of an endogenous human regulatory role or an approved clinical effect.

How can a laboratory distinguish EDR Pinealon from other short Khavinson peptides?+

Specify H-Glu-Asp-Arg-OH, terminal state and counter-ion rather than ordering only by the trade name. Intact mass can exclude many wrong sequences, but it may not resolve every isomeric or near-isobaric short peptide. Use retention against a qualified reference plus LC-MS/MS or another sequence-informative method, and report peptide content separately from HPLC area purity, water and counter-ion.

Evidence before order

Pinealon

Key benefits

Specifications to confirm against the released lot

Identity, purity and content are separate release questions.

What researchers study about Pinealon

The question the literature is testing

Research routes and exposure context

Compatibility, limitations and decision context

Interactions reported in the literature

Pinealon batch COAs

Third-party reports for Pinealon

Ask for the current packet, not a generic certificate

Quote the fill and pack configuration you need

Plan storage before the parcel arrives

Terms to settle before the purchase order

Literature behind the research context

Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes

Pinealon protects the rat offspring from prenatal hyperhomocysteinemia

Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA

EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease

Neuroepigenetic Mechanisms of Action of Ultrashort Peptides in Alzheimer's Disease

Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes

Neuroprotective Effects of Peptide Bioregulators in People of Various Age

PubChem Compound Summary: Pinealon

Questions buyers ask about Pinealon

Buyer intelligence

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